Gabriel Alexander


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Device Closure of a Large Atrial Septal Defect in a Patient with Lung Pathology


The incidence of persuasive speech topics) is approximately 3 per 10,000 live births. Ostium secundum ASD is the most common type of ASD accounting for 75% of all ASD cases and 30% to 40% of all congenital heart disease in patients older than 40 years. Minority of patients of ASD (<1%) may develop severe pulmonary hypertension with shunt reversal.

It is a current practice to assess the reversibility of pulmonary arterial hypertension (PAH) by means of pulmonary vasodilator testing during right heart catheterization in patients with shunt related pulmonary hypertension. Patients with irreversible PAH are considered ineligible for shunt closure because of the risk of right ventricular (RV) decompensation after the intervention . It is important to test the reversibility for all cases of ASD with PAH. It is also important to look for other causes of PAH particularly lung pathology. The present case highlights how an underlying lung pathology influences the decision to close the ASD at various stages. We report such case of a lady with PAH who was followed up as Eisenmenger syndrome.

Case Report

A 56-year-old female patient presented with NYHA class IV dyspnea associated with fever and coughing for hook examples. She was managed at local hospital for lower respiratory tract infection and was discharged before 3 days. Although she was diagnosed as a case of congenital heart disease 30 years ago and she was having NYHA class II dyspnea for 10 years, no further evaluation was done. Her symptoms became worse with time, and she presented with NYHA class IV dyspnea. Her blood pressure was 102/66 mmHg, heart rate was 110/min, respiratory rate was 30/min and temperature of 100 F. A regular heart rate was detected with wide fixed splitting of S2 at the pulmonary area. Chest examination revealed bilateral extensive crepitations. She was deeply cyanosed and no clubbing of the fingers or nails was observed. Her oxygen saturation was 46% on room air and 80% on Bipap support with 100% fio2. She had similar episode of LRTI in last one year and was diagnosed as having severe PAH. She was advised medical management in view of severe PAH with cyanosis. Electrocardiography revealed sinus rhythm with right axis deviation. A transthoracic echocardiogram revealed a large ostium secundum ASD (30 mm) with bidirectional shunt. The RV was prominently dilated and revealed significantly decreased contractility and flattened interventricular septum with a D-shaped left ventricle (LV) showing normal contractility with RV dysfunction (TAPSE 6 mm). There was no significant RV hypertrophy. The systolic pulmonary arterial pressure measured by maximal tricuspid regurgitation velocity (TR Vmax) was estimated at 85 mmHg with systolic blood pressure of 102 mmHg (TR Vmax=4.6 m/sec).



In view of severe respiratory distress and desaturation, patient was intubated and put on mechanical ventilator. Her repeat echocardiography showed left to right shunting ASD  with dilated right atrium and right ventricle with pulmonary artery pressures as estimated from TR velocity of 50 mmHg against systemic pressures of 120/80 mmHg. Chest X-ray showed cardiomegaly and a dilated pulmonary trunk with haziness in bilateral lower zone. Klebsiella pneumonias was isolated from sputum culture and CT chest showed right lower lobe bronchiectasis with infective changes. She was managed with antibiotics, diuretics, and other supportive measures. She was extubated a week later and was maintaining Spo2 90% to 92% on Bipap support. However repeated attempts to wean patient off Bipap support were unsuccessful. Patient continued to receive supportive care and Ambrisentan.



Subsequently cardiac catheterization and Balloon occlusion of ASD revealed significant shunt with Qp/Qs ratio of 8:1 with step up in oxygen saturation of 19%. Mean pulmonary artery pressure was 35 mmHg (systemic pressure 112/80 mmHg). She underwent device closure for ASD with AMPLATZER septal occluder (36 mm) (AGA Medical Corp., Minneapolis, MN, USA). No residual leak was observed on the follow up transthoracic echocardiography. The patient was given antiplatelet therapy with rhetorical analysis essay example. Finally, her physical activity and symptoms were much improved. A chest X-ray showed remarkably decreased pulmonary vascularity, but cardiomegaly remained. Follow up transthoracic echocardiography showed ASD device in situ, increased left atrial and LV chamber size. RV size had decreased significantly, and RV contractility was improved in comparison with the initial study. TR Vmax also decreased markedly from 4.6 m/sec to 3.1 m/sec with maximum pressure gradient of 40 mmHg. She is being regularly followed up in OPD and at 3 months of follow up systolic pulmonary arterial pressure was 36 mmHg (measured by maximal tricuspid regurgitation velocity).


There have been a lot of questions about safety and efficacy of patients with PAH who undergo surgical or percutaneous ASD closure. Closure of such shunts is associated with decrease of cardiac output and increase of right sided heart failure and death. Thus, defect closure in these patients should be performed only if the benefits of abolishing the shunt outweigh the risks of surgical or percutaneous closure. It is important to search for other causes of PAH particularly pulmonary cause.

So, the decision for ASD closure has to be taken keeping in view wholesome approach to the patient including clinical data, echocardiographic findings and cardiac catheterisation data. We had an elderly lady who presented with repeated chest infections. This propensity to chest infection was relatively increased in view of bronchiectatic changes in the lung. Each evaluation at the time of chest infection was suggestive of severe PAH. The decision to close the defect was made after treatment of chest infection. Even after the chest infection subsided, increased blood flow to the other segments of the lung did not allow the patient to be weaned off Bipap support. ASD shunt which would otherwise have been well tolerated became intolerable as this was superimposed on bronchiectasis.


Studies have reported that informative speech topics factors including pulmonary vasoconstriction and endothelial dysfunction related to hypoxic state such as chronic lung disease, left ventricular dysfunction and thrombogenic factors have been implicated in and may contribute to, aggravation of long standing shunt related PAH . Our patient also had bronchiectatic changes in lung which might have aggravated ASD related PAH. Moreover, high pulmonary blood flow related to ASD might have worsened the lung pathology which led to lower respiratory tract infection and ultimately respiratory failure in our patient. She showed rapid improvement and was successfully weaned off Bipap support after percutaneous ASD closure.